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FTY720(Fingolimod HCL)

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产品名称: FTY720(Fingolimod HCL)
产品型号: C13690
产品展商: Chembest
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简单介绍

免疫抑制剂又称现货供应FTY720(Fingolimod HCL)/盐酸芬戈莫德对照品 英文名:FTY720(Fingolimod HCL) 分子式:C19H33NO2.HCl 分子量: 343.9 纯度: >99% CAS No: 162359-56-0


FTY720(Fingolimod HCL)  的详细介绍
免疫抑制剂英文名:FTY720(Fingolimod HCL)
化学名称:2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol, hydrochloride
分子式:C19H33NO2.HCl
分子量: 343.9
纯度: >99%
CAS No: 162359-56-0
FTY720 is a derivative of ISP-
1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs. FTY720 is phosphorylated by sphingosine kinase, which then acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P1, S1P3, S1P4, and S1P5). Down-regulation of S1P1 receptors on T and B lymphocytes by FTY720 results in defective egress of these cells from spleen, lymph nodes, and Peyer’s patch.  FTY720 also enhances the activity of the sphingosine transporter Abcb1 and the leukotriene C4 transporter Abcc1 and inhibits cytosolic phospholipase A2 activity.
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