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现货供应Ramatroban/雷马曲班

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产品名称: 现货供应Ramatroban/雷马曲班
产品型号: C14084
产品展商: Chembest
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简单介绍

别名:3R-(4-氟苯磺酰氨基)-1,2,3,4-四氢化-9H-咔唑-9-丙酸 化学名称:3R-[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-. carbazole-9-propanoic acid 英文名:Ramatroban 分子式:C21H21FN2O4S 分子量:416.47 纯度: >99% 外观: White to Of


现货供应Ramatroban/雷马曲班  的详细介绍

别名:3R-(4-氟苯磺酰氨基)-1,2,3,4-四氢化-9H-咔唑-9-丙酸
化学名称:3R-[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-. carbazole-9-propanoic acid
英文名:Ramatroban
分子式:C21H21FN2O4S
分子量:416.47
纯度: >99%
外观: White to Off-white powder
CAS No:116649-85-5

 Biological Activity:
The biological effects of prostaglandin D2 (PGD2) are transduced by at least two 7-transmembrane G-protein coupled
eceptors, designated DP1 and DP2/CRTH2.Ramatroban is an approved human medication for the treatment of allergic
rhinitis that has documented activity as an antagonist of the thromboxane receptor (TP receptor). Ramatroban is also an
antagonist of the DP2 receptor with IC50 values of 100-170 nM.2 Ramatroban is more potent at the DP2 receptor than the
TP receptor by 4-5 fold. Ramatroban is therefore a useful tool for  the elucidation of PGD2/DP2 function in eosinophils,
basophils, and other cells of the TH2 cell-type.
 
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