现货供应对照品Pelitinib(EKB-569)/培利替尼

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产品名称: 现货供应对照品Pelitinib(EKB-569)/培利替尼

产品型号: C13994

产品展商: Chembest

产品文档: 无相关文档

简单介绍

Chemical Name: (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide Synonym: WAY-EKB-569,WAY-EKB 569,NSC729742,WAY-172569,D05399 Molecular Formula:

现货供应对照品Pelitinib(EKB-569)/培利替尼 的详细介绍

Chemical Name: (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide
Synonym: WAY-EKB-569,WAY-EKB 569,NSC729742,WAY-172569,D05399
Molecular Formula: C24H23ClFN5O2
Molecular Weight: 467.92
Purity: >99%
CAS No.： 257933-82-7
Biological Activity:
A tyrosine kinase inhibitor that is used to prepare formulation for treating primary or secondary cancer.Pelitinib is a 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity. EKB-569 irreversibly binds covalently to epidermal growth factor receptors (EGFR) ErbB-1, -2 and -4, thereby inhibiting receptor phosphorylation and signal transduction and resulting in apoptosis and suppression of proliferation in tumor cells that overexpress these receptors. EKB-569 inhibits EGF-induced phosphorylation of EGF-R and the growth of tumors that overexpress EGF-R in animal models.

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