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现货供应TAK-242(Resatorvid)/瑞沙托维

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产品名称: 现货供应TAK-242(Resatorvid)/瑞沙托维
产品型号: C14205
产品展商: Chembest
产品文档: 无相关文档

简单介绍

Synonym: Resatorvid Molecular Formula: C15H17ClFNO4S Molecular Weight: 361.82 Appearance: Light yellow solid Purity: >98% ee CAS No.: 243984-11-4


现货供应TAK-242(Resatorvid)/瑞沙托维  的详细介绍
Synonym: Resatorvid
Molecular Formula: C15H17ClFNO4S
Molecular Weight: 361.82
Appearance: Light yellow solid
Purity: >98% ee
CAS No.: 243984-11-4
Biological Activity:
TAK-242 (resatorvid), a small-molecule-specific inhibitor of Toll-like receptor (TLR) 4 signaling, inhibits the production of lipopolysaccharide-induced inflammatory mediators by binding to the intracellular domain of TLR4. Cys747 in TLR4 has been identified previously as the binding site of TAK-242. However, the mechanism by which TAK-242 inhibits TLR4 signaling after binding to TLR4 remains unknown. The present study demonstrated, using coimmunoprecipitation, that TAK-242 interferes with protein-protein interactions between TLR4 and its adaptor molecules
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