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尼达尼布 Nintedanib CAS:656247-17-5

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产品名称: 尼达尼布 Nintedanib CAS:656247-17-5
产品型号: C13378
产品展商: Chembest
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简单介绍

BIBF-1120(Nintedanib,Vargatef)


尼达尼布 Nintedanib CAS:656247-17-5  的详细介绍
尼达尼布

Product Name:BIBF-1120(Nintedanib,Vargatef)
 
CAS No.:656247-17-5
 
Synonym:Nintedanib; BIBF 1120;Intedanib; Vargatef
 
Chemical name:(Z)-methyl 3-((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenylamino)(phenyl)methylene)-2-oxoindoline-6-carboxylate;methyl (3Z)-2-hydroxy-3-[({4-[N-methyl-2-(4-methylpiperazin-1-yl)acetamido]phenyl}amino)(phenyl)methylidene]-3H-indole-6-carboxylate
 
Molecular formula:C31H33N5O4
 
Molecular weight:539.62
  
Purity(HPLC):≥99%

Biological Activity:
BIBF 1120 is a triple receptor tyrosine kinase inhibitor, blocking signaling through VEGFR (IC50 = 13-34 nM), PDGFR (IC50 = 59-65 nM), and FGFR (IC50 = 37-610 nM). As all of these receptors are involved in angiogenesis, BIBF 1120 has utility in diseases that require new vessel formation. For example, BIBF 1120 has potential applications in various forms of cancer and pulmonary fibrosis.
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