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ONO-4059 analog(GS-4059 analog) CAS:1351635-67-0

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产品名称: ONO-4059 analog(GS-4059 analog) CAS:1351635-67-0
产品型号: C16567
产品展商: Chembest
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ONO-4059 analog(GS-4059 analog)


ONO-4059 analog(GS-4059 analog) CAS:1351635-67-0  的详细介绍
Product Name:ONO-4059 analog(GS-4059 analog)
 
CAS No.:1351635-67-0
 
Synonym:ONO-4059 analogue
 
Chemical name:(R)-9-(1-acryloylpiperidin-3-yl)-6-amino-7-(4-phenoxyphenyl)-7H-purin-8(9H)-one
 
Molecular formula:C25H24N6O3
 
Molecular weight:456.50
  
Purity(HPLC):≥99%

Biological Activity:
ONO-4059 is a highly potent and selective Btk inhibitor with an IC50 in the sub-nM range.
ONO-4059 is a selective, once-daily, oral inhibitor of BTK, which has been shown to play a role in the survival and proliferation of malignant B-cells. ONO-4059 shows a favourable safety profile along with promising efficacy in this difficult-to-treat patient population.
ONO-4059 has demonstrated anti-tumour activity in several pre-clinical models. ONO-4059 potently and dose-dependently reverse clinical arthritis and prevented bone damage in the CIA
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