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现货供应NVP-TAE684-TAE 684 对照品

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产品名称: 现货供应NVP-TAE684-TAE 684 对照品
产品型号: C13950
产品展商: Chembest
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简单介绍

Synonym: NVP-TAE 684 Chemical Name: 5-chloro-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-2,4-Pyrimidinediamine Molecular Formula: C30H40C


现货供应NVP-TAE684-TAE 684 对照品  的详细介绍
Synonym: NVP-TAE 684
Chemical Name: 5-chloro-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-2,4-Pyrimidinediamine
Molecular Formula:  C30H40ClN7O3S
Molecular Weight:  614.22
Appearance: Yellow solid
Purity: >99%
CAS No.: 761439-42-3
Biological Activity:
A highly potent and selective smallmolecule ALK inhibitor, which blocked the growth of ALCL-derived and ALK-dependent cell lines with IC50 values between 2 and 10 nM.NVP-TAE684 treatment resulted in a rapid and sustained inhibition of phosphorylation of NPM-ALK and its downstream effectors and subsequent induction of apoptosis and cell cycle arrest.In vivo, NVP-TAE684 suppressed lymphomagenesis in two independent models of ALK-positive ALCL and induced regression of established Karpas-299 lymphomas.
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