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现货供应Temozolomide/替莫唑胺

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产品名称: 现货供应Temozolomide/替莫唑胺
产品型号: C14235
产品展商: Chembest
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简单介绍

英文名:Temozolomide 分子式:C6H6N6O2 分子量: 194.15 外观: White to off-white crystalline powder 溶解性: Soluble in DMSO (20 mg/mL); slightly soluble in water 纯度: >99% CAS No: 85622-93-1


现货供应Temozolomide/替莫唑胺  的详细介绍
英文名:Temozolomide
分子式:C6H6N6O2
分子量: 194.15
外观: White to off-white crystalline powder
溶解性: Soluble in DMSO (20 mg/mL); slightly soluble in water
纯度: >99%
CAS No: 85622-93-1
Biological Activity:
 
 Temozolomide is an antitumor, antiangiogenic compound, that has been shown to work by alkylating DNA; typically through addition of a methyl group to guanine in genomic DNA. The efficacy of this compound is dependent on its ability to methylate the DNA, thus triggering apoptosis; however, some cells are able to repair this damage via the enzymes MGMT (O-6-methylguanine-DNA methyltransferase). As a consequence Temozolomide is far more efficacious in tumor cells that have silenced this repair enzyme. Research has also been conducted to determine whether MGMT inhibitors such as O-6-benzylguanine might help to increase the efficacy of Telozolomide. Furthermore, Temozolomide has been implicated in causing arrest at the G2-M cell cycle checkpoint, which might also play a role in its cytotoxicity

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