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现货供应对照品Fondaparinux sodium(D01844)/磺达肝癸钠

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产品名称: 现货供应对照品Fondaparinux sodium(D01844)/磺达肝癸钠
产品型号: C13683
产品展商: Chembest
产品文档: 无相关文档

简单介绍

Chemical Name: decasodium (2R,3S,4S,5R,6R)-3-[(2R,3R,4R,6R)-5-[(2R,3R,4S,5S,6S)-6-carboxylato-5-[(2R,3R,4R,5S,6R)-4,5-dihydroxy-3-(sulfonatoamino)-6-(sulfonatooxymethyl)oxan-2-yl]oxy-3,4-dihydroxy-oxa


现货供应对照品Fondaparinux sodium(D01844)/磺达肝癸钠  的详细介绍
Chemical Name: decasodium (2R,3S,4S,5R,6R)-3-[(2R,3R,4R,6R)-5-[(2R,3R,4S,5S,6S)-6-carboxylato-5-[(2R,3R,4R,5S,6R)-4,5-dihydroxy-3-(sulfonatoamino)-6-(sulfonatooxymethyl)oxan-2-yl]oxy-3,4-dihydroxy-oxan-2-yl]oxy-3-(sulfonatoamino)-4-sulfonatooxy-6-(sulfonatooxymethyl)oxan-2-yl]oxy-4-hydroxy-6-[(2R,3S,4R,5R,6S)-4-hydroxy-6-methoxy-5-(sulfonatoamino)-2-(sulfonatooxymethyl)oxan-3-yl]oxy-5-sulfonatooxy-oxane-2-carboxylate
别名:Arixtra,D0184
英文名:Fondaparinux sodium
分子式:C31H43N3Na10O49S8
分子量:1728.08
纯度:>98%
CAS:114870-03-0
Biological Activity:
Antithrombotic, indirect and selective synthetic factor Xa inhibitor; Fondaparinux is a synthetic and specific inhibitor of activated Factor X (Xa) with no animal sourced components. The anti-thrombotic activity of fondaparinux is the result of antithrombin III (ATIII) mediated selective inhibition of Factor Xa. By binding selectively to ATIII, fondaparinux potentiates (about 300 times) the innate neutralisation of Factor Xa by antithrombin. Neutralisation of Factor Xa interrupts the blood coagulation cascade and inhibits both thrombin formation and thrombus development.  Fondaparinux does not inactivate thrombin (activated Factor II) and has no effects on platelet aggregation. It does not cross-react with sera from patients with heparin-induced thrombocytopenia. At the recommended dose, it does not affect fibrinolytic activity or bleeding time. At equivalent anti-thrombotic doses, an experimental bleeding model in rats demonstrates that fondaparinux induces less bleeding than unfractionated heparin.
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