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甲基泼尼松龙(甲基强的松龙) Methylprednisolone CAS:83-43-2

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产品名称: 甲基泼尼松龙(甲基强的松龙) Methylprednisolone CAS:83-43-2
产品型号: C14857
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简单介绍

Product Name:Methylprednisolone CAS No.:83-43-2


甲基泼尼松龙(甲基强的松龙) Methylprednisolone CAS:83-43-2  的详细介绍

Product Name:Methylprednisolone


CAS No.:83-43-2


Molecular Formula:C22H30O5


Molecular Weight:374.48


Appearance:White crystalline powder


Identification (IR,HPLC):White crystalline powder


Assay(UV, basis on drying):>98%


生物活性:
Methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties.
Target: Glucocorticoid Receptor
Methylprednisolone is typically used for its anti-inflammatory effects. Common uses include arthritis therapy and short-term treatment of bronchial inflammation or acute bronchitis due to various respiratory diseases. Methylprednisolone is used both in the treatment of acute periods and long-term management of autoimmune diseases, most notably systemic lupus erythematosus. It is also used for vestibular neuritis [1].
After six months the patients who were treated with methylprednisolone within eight hours of their injury had significant improvement as compared with those given placebo in motor function (neurologic change scores of 16.0 and 11.2, respectively; P = 0.03) and sensation to pinprick (change scores of 11.4 and 6.6; P = 0.02) and touch (change scores, 8.9 and 4.3; P = 0.03). Benefit from methylprednisolone was seen in patients whose injuries were initially evaluated as neurologically complete, as well as in those believed to have incomplete lesions [2].


相关文献:
[1]. Strupp, M., et al., Methylprednisolone, valacyclovir, or the combination for vestibular neuritis. N Engl J Med, 2004. 351(4): p. 354-61.
[2]. Bracken, M.B., et al., A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. Results of the Second National Acute Spinal Cord Injury Study. N Engl J Med, 1990. 322(20): p. 1405-11.

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