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Picropodophyllotoxin CAS:477-47-4

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产品名称: Picropodophyllotoxin CAS:477-47-4
产品型号: C16593
产品展商: Chembest
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简单介绍

苦鬼臼毒素 Product Name:Picropodophyllotoxin CAS No.:477-47-4


Picropodophyllotoxin CAS:477-47-4  的详细介绍
苦鬼臼毒素
Product Name:Picropodophyllotoxin
CAS No.:477-47-4
Synonyms:Picropodophyllin;AXL-1717
Chemical Name:(5R,5aS,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
Structure:Picropodophyllotoxin CAS 477-47-4
Purity:>97 %
Molecular Formula:C22H22O8
Molecular Weight:414.41
Biological Activity:
AXL1717 (Picropodophyllotoxin) is an orally active insulin-like growth factor-1 receptor (IGF-1R) inhibitor with IC50 of 1 nM; exhibits little effect towards IR, FGFR, PDGFR and EGFR, and exerts no effects on microtubules and DNA topoisomerase II.
IC50 value: 1 nM(IGF1R autophosphorylation)
Target: IGF1R
AXL1717 inhibits IGF1R autophosphorylation (IC50 ~ 1 nM), increases the fraction of cells in the G2/M phase and upregulates apoptosis. AXL1717 exhibits antiproliferative effects in multiple cancer cell lines (IC50 = 0.05 - 15 μM), and has anticancer and antineovascularization activity in vivo.
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