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Clozapine N-oxide CAS:34233-69-7

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产品名称: Clozapine N-oxide CAS:34233-69-7
产品型号: C16478
产品展商: Chembest
产品文档: 无相关文档

简单介绍

Product Name:Clozapine N-oxide CAS:34233-69-7 Molecular Formula:C18H19ClN4O Molecular Weight:342.82


Clozapine N-oxide CAS:34233-69-7  的详细介绍
Product Name:Clozapine N-oxide
CAS:34233-69-7
Molecular Formula:C18H19ClN4O

Molecular Weight:342.82

Appearance:Light yellow to yellow Solid

Purity by HPLC:>98.0%

 

Biological activity: 

IC50 Value: N/A

Clozapine N-oxide is a major metabolite of Clozapine (sc-200402) noted to decrease SR-2A (5-HT2 serotonin receptor) density in vitro. Clozapine N-oxide was noted to decrease 5-HT2 serotonin receptor density in rat primary cortical cells and human hippocampal SHS5Y5 neuroblastoma cells.
in vitro: Clozapine and N-desmethylclozapine antagonized 5-HT-stimulated phosphoinositide hydrolysis with IC50 values of 110 and 29.4 nM, respectively. Clozapine N-oxide was less potent [1].
in vivo: When administered clozapine, mean CNO plasma concentrations of 17.7 +/- 16.4 ng/ml were slightly lower than the other clozapine metabolite-desmethylclozapine (DCLOZ) plasma levels of 24.4 +/- 8.6 ng/ml at the 12 hour time point. When CNO was administered, plasma concentrations at the 12 hour time point of clozapine were twice the amount of CNO (28.1 +/- 8.9 ng/ml vs 14.4 +/- 8.8 ng/ml) [2]. Clozapine and its metabolite clozapine-N-oxide (0.5 mg/kg) were administered intraperitoneally to guinea-pigs. Significant amounts of clozapine were detected in plasma, liver, frontal cortex and caudate after clozapine-N-oxide administration [3].
Toxicity: N/A
Clinical trial: N/A

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