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现货供应TW-37对照品

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产品名称: 现货供应TW-37对照品
产品型号: C14300
产品展商: Chembest
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简单介绍

别名:TW-37 分子式:C33H35NO6S 分子量:573.7 外观:White solid 纯度:>98% CAS:877877-35-5


现货供应TW-37对照品  的详细介绍
别名:TW-37
分子式:C33H35NO6S
分子量:573.7
外观:White solid
纯度:>98%
CAS:877877-35-5
Biological Activity:
TW-37 binds to the BH3 binding groove in Bcl-2 protein competing with BH3 peptides derived from Bid, Bim, and Bad proteins. TW-37 binds to Bcl-2 with a K(i) value of 290 nM and also to Bcl-xL and Mcl-1 with high affinities.TW-37 potently inhibits cell growth in PC-3 prostate cancer cells with an IC50 value of 200 nM and effectively induces apoptosis in a dose-dependent manner. TW-37 has an IC50 of 1.1 µmol/L for primary human endothelial cells and averaged 0.3 µmol/L for head and neck cancer cells (OSCC3,UM-SCC-1, and UMSCC-74A). The combination of TW-37 and cisplatin showed enhanced cytotoxic effects for endothelial cells and HNSCC in vitro, compared with single drug treatment.
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